AU project

Applying deep-learning techniques to identification of pathogenic amino acid substitutions by means of Recurrent Neural Networks

Over the past decade deep learning techniques have achieved great success in such application as face recognition, text-mining, text-generation etc. And this technique found its application in computational biology as well. One of its branches accommodates the functional analysis of protein molecules. It's well known that protein function can be dramatically changed by substitutions of single amino acids.

A scaled hypersphere search method for the topography of reaction pathways on the potential energy surface

Global reaction route mapping, a fully-automated search for all important reaction pathways relevant to a given purpose, on the basis of quantum chemical calculations enables systematic elucidation of complex chemical reaction mechanisms. Scaled hypersphere search — an algorithm for finding pathways to transition states or dissociation channels from equilibrium structures on the potential energy surface is implemented.

Study of structure responsible for biofilm formation and quorum-sensing genes in Vibrio cholerae isolated at the Far East of Russia

Vibrio cholerae is the causative agent of acute dehydrating diarrheal disease that occurs in epidemic form. It is considered that the first six pandemics were caused by V. cholerae of classical biovar however the last pandemic, started in 1961, was caused by biovar El Tor. Russia has a risk of cholera importations because of occurrence of cholera foci in Asian countries. Two key factors for environmental survival of vibrions are the ability to form biofilms and quorum-sensing mechanism — a process of cell–cell communication.

Applying cancer subpopulations analysis methods to metagenomic series

In many metagenomic studies, multiple similar metagenomic samples are available forming time- or spatial- series. In theory, such series provide unprecedented opportunities for decomposition of the mixtures of closely-related bacterial strains.


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